Methotrexate

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Suzhou Evermed Biomedical Co., Ltd

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

8/10

Product Information

  • Certification:CE
  • Warranty:1 year

Description

 Evermed Methotrexate Homogeneous Enzyme Immunoassay
*  CLINICAL IPLICATIONS
     Methotrexate is an antineoplastic drug used solely or in combination with other antineoplastic drugs for the treatment of leukemia and other diseases [1-2]. Relatively low doses of methotrexate (approximately 7.5-25 mg/week) have been used in the treatment of nonmalignant diseases such as severe psoriasis, asthma, rheumatoid arthritis sarcoidosis, and transplantation therapy[3-4]. Intermediate to high doses of methotrexate (approximately 35mg/m2 -12g/m2) with leucovorin (citrovorum-factor) rescue have been used with favorable results in the treatment of osteogenic sarcoma, leukemia, non-Hodgkin’s lymphoma, lung and breast cancer [5]. The efficacy of methotrexate in the treatment of other tumors such as prostatic cancer is being investigated.
 *  TEST SAMPLE
Serum, Plasma
 * KEY POINTS
  • Our assay is Homogenous Enzyme Immunoassay (HEIA), which covers a full range of product portfolio with excellent performance and continuous innovations.
  • Ready-to-use reagents that can be loaded on to all kinds of automated chemistry analyzers.
  • Assays are liquid-stable and convenient to use —with no waste or reconstitution; no sample preparation and contain nonhazardous preservatives.
  *   REFERENCES

[1] Jonsson OG, Kamen BA. Methotrexate and childhood leukemia, Cancer Investigation 1991; 9(1):53-60.

[2] Bleyer WA. The clinical pharmacology of methotrexate: New applications of an old drug. Cancer 1978; 41:36-51.

[3] Hosenpud JD, et al. Methotrexate for the treatment of patients with multiple episodes of acute cardiac allograft rejection. J Heart Lung Transplant 1992; 11: 739-45.

[4] Baughman RP, Lower EE. The effect of corticosteroid or methotrexate therapy on lung lymphocytes and macrophages in sarcoidosis. Am Rev Respir Dis 1990; 142: 1268-71.

[5] Abromowitch M, et al. High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude total therapy study X. Medical and Pediatric Oncology 1988; 16: 297-303.


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