Mycophenolic Acid

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Suzhou Evermed Biomedical Co., Ltd

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

8/10

Product Information

  • Certification:CE
  • Warranty:1 year

Description

Evermed Mycophenolic Acid Homogeneous Enzyme Immunoassay
 *   CLINICAL IMPLICATIONS
  Mycophenolic Acid (MPA) is an immunosuppressant drug derived from fungus Penicillium echinulatum.[1]  MPA is commonly used in order to prevent tissue rejection following organ transplantation, and more recently to treat certain autoimmune diseases. MPA therapy has optimal safety and efficacy over a narrow range of concentrations and may lead to a number of adverse effects. The most critical adverse effects are acute organ rejection from inadequate dosing, or gastrointestinal disturbances, hematologic disorders (leucopenia and anemia), and infections when drug concentration becomes too high. According to study MPA exposure may vary with time and interfering medications. It is essential to monitor MPA in organ transplantation patients to achieve optimal immunosuppressive effects. [2-6]
 *  TEST SAMPLE TYLE  
Serum, Plasma 
  *  KEY POINTS
  • Our assay is Homogenous Enzyme Immunoassay (HEIA), which covers a full range of product portfolio with excellent performance and continuous innovations.
  • Ready-to-use reagents that can be loaded on to all kinds of automated chemistry analyzers.
  • Assays are liquid-stable and convenient to use —with no waste or reconstitution; no sample preparation and contain nonhazardous preservatives.
*    REFERENCES

 [1] Anderson, HA; Bracewell, JM; Fraser, AR; Jones, D; Robertson, GW; Russell, JD (December 1988). "5-Hydroxymaltol and mycophenolic acid, secondary metabolites from Penicillium echinulatum" (PDF). Transactions of the British Mycological Society. 91 (4): 649–651.

[2] Kuypers, D.R., Le Meur, Y.L., Cantarovich, M. et al (2010) Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation. Clin J Am Soc Nephrol. 2010;5:341–358.

[3]Regueira, T. B.; Kildegaard, K. R.; Hansen, B. G.; Mortensen, U. H.; Hertweck, C.; Nielsen, J. (2011).  "Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum". Applied and Environmental Microbiology 77 (9): 3035–3043.

[4]Allison, Anthony C (2000).


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